CAMERON REY-DUBOIS

Cameron is an undergraduate student interested in the pathophysiology of chronic inflammatory diseases, such as inflammatory bowel disease (IBD). He completed his Honours project in 2023 examining the systemic manifestations of gastrointestinal inflammation on the spleen in a murine model of colitis. This was evaluated using hematological and histological studies to assess splenic function in our model. Cameron also studied the role of the novel hormone and receptor pair, insulin-like peptide 5 (INSL5) and relaxin family peptide receptor-4 (RXFP4), on inflammatory signaling using cultured splenic dendritic cells from our mice. The results of Cameron’s project may serve to better understand the mechanisms leading to reduced splenic function in human IBD patients, as well as to further test the role of INSL5-RXFP4 in maintaining homeostasis of the immune system.